Mat Tait makes his comeback for Leicester after 13 months out injured in Friday night's LV=Cup match at Saracens.
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The former England international is named on the bench for the match which takes place at Bedford's Goldington Road - the 11th venue Saracens have used in as many matches this season.
Sarries name a side that has a mixture of youth and experience with players such as Sam Stanley, Ben Ransom, James Short, Ben Spencer and Nick Auterac lining up alongside the likes of Joe Maddock, Nils Mordt, Petrus du Plessis and Alistair Hargreaves.
Jono Ross is in line to make his Saracens debut after being named at No 8 and there could be further debuts with Lorenzo Romano, Max Crumpton and Nick Tompkins named on the bench.
The Tigers are led by Matt Cornwell, his first senior appearance for Leicester since his return to the club from Italian side Mogliano in the summer.
French flanker Lucas Guillaume makes his senior debut for Tigers alongside fellow debutant Michael Noone and Richard Thorpe - signed from London Irish in the summer - in the back row.
Saracens: 15 Ben Ransom, 14 Joe Maddock, 13 Duncan Taylor, 12 Sam Stanley, 11 James Short, 10 Nils Mordt, 9 Ben, Spencer, 1 Nick Auterac, 2 Jamie George, 3 Petrus du Plessis, 4 George Kruis, 5 Alistair Hargreaves, 6 Nick Fenton-Wells, 7 Andy Saull, 8 Jono Ross
Replacements: 16 Max Crumpton, 17 John Smit, 18 Lorenzo Romano, 19 Eoin Sheriff, 20 Matt Hankin, 21 Luke Baldwin, 22 Nick Tompkins, 23 Nathan Earle
Leicester: 15 Niall Morris, 14 Henry Purdy, 13 Andy Forsyth, 12 Andrew Symons, 11 Alex Lewington, 10 Matt Cornwell, 9 Micky Young, 1 Jonny Harris, 2 Jimmy Stevens, 3 Kieran Brookes, 4 Rob Andrew, 5 Joe Cain, 6 Lucas Guillaume, 7 Richard Thorpe, 8 Michael Noone
Replacements: 16 Harry Thacker, 17 Fraser Balmain, 18 Ryan Bower, 19 George Oliver, 20 Tom Price, 21 Sam Harrison, 22 George Ford, 23 Mathew Tait
What they said...
Saracens Director of Rugby Mark McCall
"We face the reigning LV=Cup champions and we know that Leicester will come to us wanting to defend that trophy.
"We have to meet that challenge and expect the fierce level of competition that we always do against the Tigers - whatever the competition or venue."