London Welsh head coach Lyn Jones makes 11 changes to his side for the visit of I Cavalieri Prato, as the Exiles bid to end a run of four games without a victory.
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Tom Arscott, Seb Jewell, Nick Scott and Ed Jackson are the only survivors from the starting line-up which lost 31-26 to Harlequins last weekend.
Ed Williamson returns to action for the first time since sustaining a knee injury against the Italians in October and will start on the bench.
In the reverse fixture last year, London Welsh edged a thriller 32-31 to secure their first ever European victory.
Jones told the club's website: "It was a great game over there and we received a warm welcome in Prato, which we want to reciprocate on Saturday.
"Typical of where we are at this stage of European competition we have a few injuries, but we're fielding a side that can do a job.
"For us to do well in our remaining nine Aviva Premiership fixtures we need to have a full and fit squad to be competitive. I keep on telling players to please put your hand up, learn, put in a strong performance and you'll get your chance."
London Welsh: 15 Tom Arscott, 14 Phil MacKenzie, 13 Seb Jewell (c), 12 James Lewis, 11 Nick Scott, 10 Alex Davies, 9 Tyson Keats; 1 Tom Bristow, 2 Dan George, 3 Greg Bateman, 4 Adam Brown, 5 Matt Corker, 6 Lee Beach, 7 Mike Denbee, 8 Ed Jackson.
Replacements: 16 Gareth Evans, 17 Billy Moss, 18 James Tideswell, 19 Jonathan Mills, 20 Ed Williamson, 21 Nick Runciman, 22 Ryan Davis, 23 Simon Whatling.
I Cavalieri Prato: 15 Michele Sepe, 14 Niccolò Tempestini, 13 Denis Majstorovic, 12 Ross McCann, 11 Billy Ngwaini, 10 Simone ragusi, 9 Marco Frati; 1 Alessandro Borsi, 2 Andrea Lupetti, 3 Guillermo Roan, 4 Alessandro Boscolo, 5 Rome Nifo Tautua, 6 Alfonso Damiani, 7 Diego Delnevo, 8 Alberto Saccardo.
Replacements: 16 Niccolò Cannone, 17 Lorenzo Giovanchelli, 18 Giuseppe Boggiani, 19 Marco Pelizzari, 20 Pino Patelli, 21 Ivan Crestini, 22 Alessandro Lunardi, 23 Andrea Pozzi.