London Broncos find themselves without the services of skipper Craig Gower for Sunday's trip to Huddersfield.
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The former Italy rugby union international picked up a groin injury in the opening-weekend loss to Widnes and will not feature at the John Smith's Stadium.
Coach Tony Rea is also missing Michael Robertson (ankle) and David Howell, who suffered a broken arm against the Vikings at the Twickenham Stoop.
With holes to fill in the back line, off-season recruit Shane Grady is likely to make his Super League debut in the centres.
Rea has also included Liam Colbon, Michael Channing and Mike McMeeken in his 19-man squad as the capital club look to bounce back from a disappointing 28-14 reverse on home turf.
Huddersfield, in contrast, enjoyed the perfect start to the new campaign with a resounding 40-4 triumph over St Helens in front of the Sky Sports cameras on Saturday.
Coach Paul Anderson has named new signing Ukuma Ta'ai in his 19-man squad in place of Dale Ferguson, who has joined top-flight rivals Hull KR on loan.
However, the Tongan forward may have to wait to make his Giants debut after only arriving in the country on Tuesday.
Instead the hosts are likely to be unchanged from the line-up that performed so impressively at Langtree Park, securing their first win away at Saints since November 1978 in emphatic fashion.
"Ukuma is a natural replacement for Ferguson within the 19 and gives us some more options ahead of the game," Anderson told the club's official website.
"We don't yet know his best position as it's very, very early days for him, but the reality is he has come to play and looks in reasonable shape although he will clearly get much fitter as time progresses, but at this stage he is in my thoughts for London."
Huddersfield: Grix, George, Cudjoe, Wardle, McGillvary, Brough, Robinson, Crabtree, Lunt, Kopczak, Ferres, O'Donnell, Faiumu, Patrick, Chan, Ta'ai, Murphy, Cording, Fielden.
London Broncos: Bailey, Bryant, Channing, Colbon, Dixon, Dorn, Grady, Hurst, Kaufusi, Krasniqi, Lee, Lovell, McMeeken, Melling, O'Callaghan, Randall, Rodney, Wheeldon, Witt.