New Bradford coach Francis Cummins will give debuts to Adam Sidlow, Matty Blythe and Jamie Foster for the visit of Wakefield on Sunday.
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Second rower James Donaldson is set to make his first Super League appearance for almost 12 months after recovering from a knee injury. He is likely to take the place of the injured John Bateman, while Danny Addy is expected to link up with Ben Sammut at half-back in place of the injured Luke Gale.
Australian prop Justin Poore makes his Super League debut for the Wildcats, while fellow newcomer Reece Lyne gets a chance at centre in place of the injured Lee Smith.
Prop Andy Raleigh is also injured, which could pave the way for loan signing Brad Singleton to make his debut, while coach Richard Agar will give late fitness checks to half-backs Tim Smith and Kyle Wood.
Bradford did the double over Wakefield last season, but it was the Wildcats who reached the play-offs after a stirring fnish to the campaign.
Agar told the Wakefield club website: "As the year went on we learnt how to win, we learnt how to handle different situations and it transpired that we got some good form going.
"This year's different in that last year we had 17 new players whereas this year we have only three. There is a lot more continuity in the squad and there is more stability which for us should equal some more consistency."
"Every coach in the competition will want a winning start; I think that goes without saying. We're playing a Bradford team with a new head coach in the form of Francis Cummins and I'm pretty sure he'll want to get that monkey off his back as early as he can.
"We want to go out there and give a performance and hopefully it's good enough to take the result and the two points. Any two points in this competition you will take and you will take it however it comes about, we're no different."
Bradford squad: Donaldson, Sidlow, Platt, Manuokafoa, Langley, Diskin, Kearney, Scruton, L'Estrange, Blythe, Lulia, Whitehead, Sammut, Addy, Olbison, C Walker, Murphy, Foster, Kear.
Wakefield squad: Mathers, Fox, Collis, Lyne, Cockayne, Sykes, Wildie, Poore, Aiton, Amor, Wilkes, Singleton, Mariano, Lauitiiti, Kirmond, Washbrook, T Smith, Wood, Annakin.