Pique Sous gave Willie Mullins his second victory in the last three renewals of the Queen Alexandra Stakes at Royal Ascot with a smart display under Ryan Moore.
The race was marred after Tiger Cliff, who was sent off the 5/2 favourite, collapsed and died of a suspected heart attack after the race.
Mullins, Ireland's champion National Hunt trainer, saddled Simenon to win the two-and-three-quarter-mile contest two years ago and Pique Sous, who nearly lost his life last October due to colic, was a heavily backed 11/4 chance to repeat the trick.
They grey, who was placed in the Champion Bumper at the Cheltenham Festival a couple of years ago and has won over hurdles as well as on the Flat, was a little keen in the early stages and Moore sensibly dropped him out towards the rear of the field.
He began to make headway heading down the back straight and was hot on the heels of the leaders rounding the home bend.
It was obvious he was travelling much better than his rivals and he quashed any doubts about his stamina to last out the trip with a determined length-and-a-half victory.
El Salvador made considerable headway late in the day to finish second, with Brass Ring another neck away in third.
The victory confirms Moore's place as leading jockey for the week, his sixth winner of the meeting and his third on the card.
Moore said: "It was a very messy race, they only went steady.
"He travelled beautifully into the race and picked up well.
"When you ride for Willie it makes it a bit easier.
"It was a long way, the last furlong, but I got the gaps when they came."
Mullins said: "Having a Royal Ascot winner is always fantastic.
"When Ryan hit the front I didn't think anyone could catch him."
Mullins said Pique Sous could now make a swift turnaround in the Northumberland Plate at Newcastle next Saturday.
He said: "It's great for the Supreme Horse Racing Club (owners).
"I picked this horse out for them as he had a lovely pedigree. It's a been a dream for the racing club to be here and enjoying this.
"He's in the Northumberland Plate, so we'll see how he comes out of that.
"I'm not sure what penalty he gets for winning this but we will have a look at that.
"I'd like to dedicate the victory to one of my members of staff who had a brain haemorrhage and who is quite ill in hospital."