William Buick and John Gosden got off the mark for the week with Remote's victory in the Tercentenary Stakes.
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The well-backed 9/4 favourite was held up in midpack in the early stages of the mile-and-a-quarter contest as Elkaayed took the field along under Paul Hanagan.
Van De Neer and Windhoek then took up the running over a furlong out and it briefly looked as if the pair would fight out the finish.
But Buick hadn't let the first two get too far clear and he - along with runner-up Shikarpour - swept past close home to score by three-quarters of a length with Van De Neer a most creditable third.
"He's done it well. We've been hitting the goalposts and the crossbars and things, but we've got one on the board," said winning trainer John Gosden.
"I said to [the colt's owner] Prince Khaled [Abdullah] that if it was firm, I wanted to pull him out, but he said 'John - we'll run' and he was right.
"It's beyond huge today. You start off with a fantastic American winner of the Norfolk, then there's the Ribblesdale won by Henry, who was a great friend and I miss him every day.
"Then there's the Gold Cup, which sits annoyingly out of reach for Her Majesty, and is finally won by her.
"I think, for me, it's seriously historical in our world."