Wizz Kid, the sole French-trained runner in the Qatar Prix De L'Abbaye de Longchamp, lifted the Group One sprint.
- Related Content
A field of 18 went to post for the five furlong contest which has been dominated by foreign raiders for much of the last four decades with only Robert Collet's four year old representing the home team.
Inxile and Hamish McGonagall broke well against the rail and the well-backed favourite Mayson was soon on their heels despite having been slowly away at the break.
The seven year old Inxile was the first to crack as Paul Hanagan manoeuvred Mayson off the rail to challenge and the pair settled down to fight it out with Tim Easterby's runner.
They looked to have the race between them but Gerald Mosse weaved his way through the field aboard Wizz Kid who, once out in the open, sluiced through the testing ground to make up about three lengths inside the final furlong and hit the front on the line.
John O'Connor, racing manager for winning owners Ballylinch Stud, said of Wizz Kid: "She's been unlucky in a couple of the big sprints before but it's nice everything has gone her way.
"She was beaten a length here last year and finished only fifth. She loved the fast pace and finished off well, so she deserves it.
"We will certainly consider going to Ascot (on Champions Day) now because she doesn't have to carry a Group One penalty there."
Mayson's trainer Richard Fahey said: "He was a little bit sloppy at the start and Paul (Hanagan) thought he was on his head the whole way, it was a bit sharp for him.
"We got mugged close home but that's racing. He's run a great race but I hate finishing second.
"He might go to Ascot now (Qipco British Champions Sprint Stakes). We'll see how he comes out of the race when we get him home."
Fellow Yorkshire trainer Tim Easterby said of the third-placed Hamish McGonagall: "He ran a mighty race. He's an absolute superstar and he's got a massive heart.
"He's got the speed for this ground, but Wizz Kid came past him like a bullet.
"We'll give him a well-earned break now, but the idea would be to come back for this next season."
Eddie Ahern partnered the Brian Meehan-trained Ballesteros to finish fourth, and said: "He gave me a great ride and he went through the ground as if it was nice going. I was delighted with his run."