Mark Johnston and Richard Hannon saddle half of the 16-runner field in Saturday's £100,000 Tattersalls Millions Median Auction Trophy at Newmarket.
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Johnston has five chances to claim the massive pot.
Johnny Murtagh is coming over to ride Lyn Valley, with Irish compatriot Fran Berry on Quickaswecan.
Lanark (Joe Fanning), Vine De Nada (Martin Lane) and Sir Guy Porteous (Dane O'Neill) are Johnston's other contenders.
The Middleham handler said: "Lanark is the top-rated horse of ours on official ratings in the race but, on Timeform, Lyn Valley is, so those are our best two horses on form.
"Quickaswecan has only run once and was second. That form alone wouldn't be good enough for this race but we would expect a big improvement on his first start.
"It's a shame Sir Guy Porteous hasn't had a run beforehand but he's a nice horse.
"Each horse deserves its chance in these sales races and I'm sure some of them will be turning out again in the next one."
Of Hannon's three, the Ryan Moore-ridden Bon Voyage would appear to hold the strongest claims after having finished second and third in two maidens.
"Bon Voyage is a good horse and we thought he would win his maiden second time at Ascot," said the Herridge handler.
"He should run well in a race like this as he's now got more experience and knows his job.
"We had to have Constantine cut (gelded) and since then his form has been much improved and he could go well.
"Speed The Plough has run well in pretty much every race this year and we hope he will run well again here."
Mick Channon's Jallota, fourth in the Prix Morny behind No Nay Never, sets a clear form standard at which to aim.