Danadana out of Cambridgeshire
Leading contender Danadana will miss the Betfred Cambridgeshire at Newmarket on September 29, trainer Luca Cumani has revealed.
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Ante-post markets have been left in a state of flux, with the sponsors other initial joint-favourite, Chil The Kite, far from certain to line-up.
Danadana had been saddled with top-weight of 9st 10lb after winning the Zetland Gold Cup at Redcar in June before following up at York.
But Cumani told his website: "(Danadana) won't be seen out again until next year - even Dubai will come too soon for him - after sustaining a bone injury."
Hughie Morrison, while not ruling it out completely, conceded a Cambridgeshire bid would not be ideal for Chil The Kite (8st 7lb), who is due to switch to Listed level at Haydock on Saturday.
He told At The Races: "Chil The Kite won at Ascot in July and he will run (at Haydock). He's been off the course for six or seven weeks now but there's very few opportunities for progressive mile three-year-olds.
"You either go in a handicap at York or go for a Group Three, and we decided that was not the right way to go in the short term and to go for a Listed race, but it's more like a Group race.
"I'm not that keen on running three-year-olds in very competitive older-horse handicaps.
"We've won these races with the likes of Supaseus (in 2009) who was inconsistent but really was a Group horse - he ran very well in Group races.
"A younger horse running at level weights against older horses is a very tough ask and it's a very tough race.
"We might end up there but it's against my better judgment, to be honest."
Other leading Cambridgeshire contenders include King's Warrior (9st 2lb), winner of the John Smith's Cup for Peter Chapple-Hyam, and William Haggas' Royal Ascot fourth Mukhadram (8st 11lb).
The heritage handicap could also feature David Simcock's Trade Storm (9st 5lb), who captured a competitive handicap at York on August 23.
He may clash again with Strictly Silver (8st 2lb), Indian Jack (8st 3lb) and Navajo Chief (9st 6lb), who finished second, third and fourth respectively on the Knavesmire.