Sir Alex Ferguson is set to hand another chance to the men who slipped to defeat against Besiktas last week when Manchester United look to reach the Carling Cup semi-finals at the expense of Tottenham at Old Trafford.
Teenage duo Federico Macheda and Danny Welbeck may start up front, although Michael Owen's experience could also be used as the holders take on the 2008 winners and last season's beaten finalists.
Rafael Da Silva could be included at right-back to give veteran Gary Neville a rest after two games in four days, while Ben Foster is expected to replace Tomasz Kuszczak in goal.
Tottenham boss Harry Redknapp is expected to shuffle his pack at Old Trafford.
Skipper Robbie Keane could be recalled along with England midfielder Jermaine Jenas after the pair started the last two matches as substitutes.
Luka Modric (fractured fibula), Ledley King (hamstring) and Jonathan Woodgate (groin) are sidelined and Niko Kranjcar is cup-tied.
Teams:
Manchester United (from): Foster, Kuszczak, Amos, Neville, De Laet, Brown, Vidic, Jonny Evans, Corry Evans, Evra, Rafael, Obertan, Valencia, Gibson, Anderson, Fletcher, Carrick, Nani, Park, Tosic, Berbatov, Rooney, Owen, King, James, Macheda, Welbeck.
Tottenham (from): Gomes, Dawson, Assou-Ekotto, Corluka, Bassong, Huddlestone, Lennon, Keane, Palacios, Jenas, Crouch, Defoe, Alnwick, Hutton, Bentley, Bale, Rose, Pavlyuchenko, Naughton.