Nicolas Anelka is an injury doubt for Bolton's trip to the French striker's old club Arsenal after picking up a knock against the Faroe Islands at the weekend.
Anelka will miss France's international against Lithuania on Wednesday and will have a fitness test before the Arsenal game.
A statement on the club's official website said: "Nicolas will be assessed by Wanderers' medical officials upon his return to the club's training ground."
Les Bleus have also lost Sevilla defender Julien Escude to injury.
A brief statement on the French Football Federation's official website said only that the injured players "left Clairefontaine and the French football team on Monday morning and would therefore be absent for Les Bleus' penultimate qualifying match".
Anelka, 28, has 42 caps to his name and 11 goals - including the opener in France's 6-0 demolition of the Faroe Islands on Saturday.
Twenty-year-old Escude has played five times for his country.
Coach Raymond Domenech has called Monaco striker Frederic Piquionne into his squad as Anelka's replacement.
The 28-year-old has just one international cap - picked up against Austria in March - but has had an impressive start to the Ligue 1 season, scoring four times in 10 matches for the principality club.