Chesterfield's new loan signing Drew Talbot is expected to go straight into Lee Richardson's squad for the home clash with Exeter.
The 22-year-old former Sheffield Wednesday striker has joined from Luton until the end of the season and could make his debut against the Grecians.
Manager Richardson will be hoping Lloyd Kerry recovers from the dead-leg that kept him out of Saturday's home defeat to Morecambe, while fellow midfielder Lee Askham will be available after extending his short-term contract until the end of the season.
Martin Gritton, signed recently from Macclesfield, is likely to start up front again and the Spireites could be boosted by the return of skipper Rob Page, who has been struggling with calf and foot injuries.
Exeter are set to be boosted by the return of fit again central defender Matt Taylor.
Taylor - sidelined by a niggling foot injury since November - was introduced from the substitutes' bench as a 61st-minute replacement for on-loan Tottenham defender Troy Archibald-Henville in Saturday's 1-0 reverse at Gillingham.
City boss Paul Tisdale again pulled a tactical surprise by employing a 4-5-1 formation.
Adam Stansfield was used as a lone striker with Neil Saunders and Jack Obersteller recalled in the wide midfield roles.
Striker Craig McAllister, who scored both City goals in the 2-1 win at Dagenham & Redbridge last week, came on as a half-time replacement for Obersteller.