Watford will check on skipper Jay DeMerit ahead of the trip to Plymouth.
The centre-half missed Saturday's 1-0 win over Barnsley with a groin injury suffered while on international duty with the USA.
Rookie defender Dale Bennett, 19, made his first start in DeMerit's place and stands by again while fellow centre-back Adrian Mariappa took the captain's armband.
New recruit Craig Cathcart, who agreed a loan switch from Manchester United on Monday, will not link up with the Hornets until after the trip to Home Park.
Boss Malky Mackay beefed up his midfield against Barnsley by recalling John Eustace and pushing Arsenal loanee Henri Lansbury alongside Danny Graham in attack.
The impressive Graham grabbed his fourth goal of the season to sink the Tykes.
Plymouth central defender Reda Johnson faces a race to be fit.
The Benin international made his first start in Saturday's 3-1 defeat at West Brom but hobbled out with a knee injury, so Hungarian Krisztian Timar stands by.
Argyle are set to be boosted by the return of right-back David McNamee, who was ruled out at the weekend by flu.
With on-loan Cardiff right-back Darcy Blake out with a hamstring injury and McNamee unavailable, Karl Duguid featured as right wing-back in a 3-4-3 formation at The Hawthorns.
Striker Cillian Sheridan, on loan from Celtic, suffered a hip injury after his introduction as a 66th-minute substitute but has shrugged off the injury and has trained with the squad.