Marc Tierney returns to the Colchester squad for the FA Cup trip to Hereford.
The defender missed Tuesday's 2-0 win over Stockport through suspension and should return at left-back.
Loanees Danny Baath, John-Joe O'Toole, Kevin Lisbie and Kayode Odejayi have all been given permission to play in the competition.
Striker Steven Gillespie is pushing for his first start since March after a number of impressive cameos from the bench this season.
Defender Paul Reid will hope to keep his place after coming through 90 minutes unscathed in midweek on his return from a long-term lay-off with a knee injury.
Lee Beevers (shoulder) and Ashley Vincent (ankle) are still sidelined and youngster Medy Elito serves the final game of his three-match ban.
New loan signings Nat Wedderburn and Jordon Mutch will be available for Hereford.
The midfield pair, from Stoke and Birmingham respectively, arrived at Edgar Street on Thursday afternoon and will be keen to prove their worth immediately.
Their arrivals follow shortly after the news Danny Blanchett extended his loan stay for a third and final month, meaning he will be available to feature. However, winger Mark Marshall has returned to parent club Swindon while Lee Morris has signed a loan deal at Mansfield.
Whether the new duo are included in John Trewick's starting XI, though, remains to be seen after Tuesday's impressive 2-1 derby triumph over Shrewsbury.
Defender Ryan Green recovered from a dead leg to start from the off and should feature this time around, while Mathieu Manset will again hope to be included in Trewick's matchday 18 following his recent return from suspension.
Long-term absentee Craig Jones (back) remains sidelined.