Wycombe striker Matt Harrold returned to haunt Brentford by scoring one penalty and missing another to give the Chairboys a 1-0 success.
Following a dull first half, the 25-year-old livened up proceedings from the spot in the 47th minute after former Chelsea defender Michael Duberry's header was handled by Karleigh Osborne.
Harrold had the perfect opportunity to double the lead 20 minutes later when James Wilson saw red for hauling down Gareth Ainsworth but saw his second penalty saved by Bees keeper Wojciech Szczesny.
Wycombe - riding high after picking up their first win in 14 games against Millwall on Saturday - were put on the back foot early on when Tottenham loanee John Bostock fired narrowly wide.
Midfielder Kevin Betsy replied with a mazy run only to see his effort saved by Arsenal loanee Wojciech before Sam Wood sent a stinging half volley crashing just over for Brentford on the stroke of half-time.
However, Brentford's charge ended there and one of Harrold's two penalties as well as Wilson's second half dismissal was enough to give Wycombe back-to-back League One victories at Adams Park.
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