Grimsby defender George Santos is struggling with hamstring and groin problems and Paul Groves will leave a decision on his availability until the last minute.
The Mariners boss must also decide whether to persevere with youngster Darren Mansaram as his lone striker or choose Michael Boulding, who is nearing full fitness after a niggling ankle injury.
Palace midfielder Shaun Derry is a doubt with a thigh problem, an injury which will keep Aki Riihilahti out, while defender Danny Granville is suspended.
Jamie Smith (hamstring) and Curtis Fleming (knee) remain sidelined, so youngster David Hunt could continue despite his own goal against Watford.