Sky Bet League Two Oxford survived a scare in their FA Cup second-round tie with Wrexham having trailed at half-time before eventually winning 2-1 to set up a clash with Charlton.
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Joe Clarke put the Skrill Premier side ahead after 29 minutes at the Racecourse Ground after he collected Dean Keates' cross in the box to fire home his fourth goal of the season.
But Dave Kitson provided a great assist for James Constable, who hit back with an equaliser for the League Two leaders nine minutes into the second half, with Ryan Williams heading home their second moments later from close range.
Chris Wilder's side, who saw off Gateshead in their first-round replay on Friday, next take on Championship strugglers Charlton at The Valley over the weekend commencing January 3.