Striker Robin van Persie is fully fit and available for Manchester United's game at Sunderland on Sunday.
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Midfielders Michael Carrick, Marouane Fellaini and Ander Herrera (all ankle) are out, as is utility man Jesse Lingard, who has a knee injury, but Antonio Valencia has recovered from the leg problem that kept him out of the defeat to Swansea.
Defenders Jonny Evans (leg), Luke Shaw (hamstring) and Marcos Rojo (awaiting work permit) are unavailable while doubts remain over right-back Rafael (groin) and striker Danny Welbeck (knee), who has also been told he can leave the club.
Sunderland head coach Gus Poyet will welcome defenders Billy Jones and Santiago Vergini back into his squad.
Jones missed the 2-2 draw with former club West Brom last weekend because of a troublesome hamstring, while Vergini is understood to have sat out because of an administrative problem - but both will be available this weekend.
That means Poyet's only significant absentee will be Italian midfielder Emanuele Giaccherini, who continues his recovery from a groin injury.
Sunderland (from): Mannone, Pantilimon, Jones, Van Aanholt, Brown, O'Shea, Vergini, Roberge, Cattermole, Bridcutt, Rodwell, Gomez, Larsson, Johnson, Buckley, Mavrias, Wickham, Fletcher, Altidore, Graham.
Manchester United (from): De Gea, Lindegaard, Amos, Rafael, Valencia, Smalling, Jones, M Keane, Blackett, James, Fletcher, Cleverley, Anderson, Young, Mata, Kagawa, Zaha, Januzaj, Van Persie, Rooney, Welbeck, Hernandez, Powell, W Keane.