Sheffield Wednesday will be without striker Connor Wickham and defender Roger Johnson for the FA Cup tie at Macclesfield.
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Wickham, who took his goals tally to nine for the season in the 2-0 win over Blackpool on New Year's Day, has not been given permission to play by parent club Sunderland, so Jermaine Johnson could return to the starting line-up in a central role.
Roger Johnson will also be missing at Moss Rose as he has completed his loan spell, but the club are in talks with parent club Wolves about him returning to Hillsborough.
Wednesday's first win in four league games against the Seasiders lifted the club out of the bottom three.