Gary Cahill and Cesar Azpilicueta will both miss Chelsea's FA Cup fifth round tie at Middlesbrough on Wednesday.
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Centre-back Cahill has been struck down by a virus ahead of the trip to the Riverside, while right-back Azpilicueta is sidelined with discomfort in his leg.
Interim manager Rafael Benitez plans to rotate his squad in a bid to deal with the busy fixture list, meaning captain John Terry may be rested. Long-term absentee Oriol Romeu continues to miss out with a knee injury.
Middlesbrough boss Tony Mowbray will be without a trio of ineligible players.
Midfielder Josh McEachran has not played in the competition to date under the terms of his loan agreement with the Blues, while Kieron Dyer and Sammy Ameobi are cup-tied.
Dyer played for former club QPR in a 1-1 third-round draw with West Brom, while Ameobi, who on Monday joined Boro on loan from neighbours Newcastle for the rest of the season, started the Magpies' 2-0 defeat at npower Championship Brighton at the same stage of the competition.
Mowbray will also be without striker Lukas Jutkiewicz (ankle) and central defender Jonathan Woodgate (calf), although the latter has a chance of returning for the league clash with league leaders Cardiff at the weekend.
In addition, Stuart Parnaby (hamstring tear), Justin Hoyte (hip) and Julio Arca (toe) remain on the sidelines.
Chelsea (from): Cech, Turnbull, Hilario, Ivanovic, Ferreira, Cole, Bertrand, Luiz, Terry, Ake, Oscar, Mata, Moses, Mikel, Lampard, Ramires, Hazard, Marin, Benayoun, Torres, Ba.