Rangers target Cammy Bell will sit out a second game in succession for Kilmarnock as he recovers from a hip injury.
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The goalkeeper, linked with a pre-contract switch to Ibrox, was replaced for Saturday's 2-0 win over Motherwell by understudy Kyle Letheran and will once more watch on from the stands as his team-mates take on Inverness at the Caledonian Stadium on Wednesday night.
Cillian Sheridan and Rory McKeown have also been ruled out of the Clydesdale Bank Premier League match after they also missed the Motherwell encounter at Rugby Park.
Ryan Esson looks set to keep hold of the Inverness number one slot after boss Terry Butcher hinted he will be his first-choice goalkeeper for the remainder of the season.
Esson missed four months with a hip injury but replaced Antonio Reguero for recent defeats to Kilmarnock and Celtic.
Butcher, whose side has a clean bill of health for Kilmarnock's visit to the Highlands, said: "Ryan has great experience and it was my call to put him back in. But Antonio is pushing him all the way."
Inverness (from): Esson, Meekings, Raven, Warren, G Shinnie, A Shinnie, Pepper, Draper, Tudur Jones, Doran, McKay, Cooper, Polworth, Ross, Roberts, Foran, Sutherland, Reguero, Devine, Taylor, Gibbons.
Kilmarnock (from): Letheren, Barbour, O'Hara, Fowler, Sissoko, Tesselaar, Dayton, Hay, Heffernan, Jaakkola, Ibrahim, Borja, Gros, Pascali, McKenzie, Clingan, Racchi, Winchester.