Newcastle boss Alan Pardew will be without midfielder Cheick Tiote for Saturday's FA Cup third round trip to npower Championship Brighton.
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The Ivory Coast international left for the African Nations Cup after Wednesday night's 2-1 Premier League defeat by Everton, and potential replacement Gael Bigirimana is battling a dead leg.
Striker Demba Ba's impending move to Chelsea has left a vacancy in attack, and while central defender Steven Taylor (hamstring) and midfielder Yohan Cabaye (groin) are back in training, they remain unavailable along with full-back Ryan Taylor (knee) and midfielders Hatem Ben Arfa (hamstring), Jonas Gutierrez, Dan Gosling and Haris Vuckic (all knee).
Brighton winger Will Buckley looks set to miss out on the chance to recreate his FA Cup heroics against the Magpies.
Buckley's deflected strike sent the Toon tumbling out of the fourth round last season, but the boyhood Newcastle fan is struggling with a hamstring injury and is not expected to be fit for the third-round rematch.
Right-back Bruno is also likely to sit out with an Achilles injury while fellow Spaniard Vicente is still not fit after a thigh problem.
Jake Forster-Caskey and Romain Vincelot are back with the Seagulls following loan spells and are available, although boss Gus Poyet is expected to field his strongest side.
Winger Kazenga LuaLua will be hoping to line up against his former club.
Newcastle squad: Krul, Elliot, Harper, Santon, Ferguson, Tavernier, Coloccini, Williamson, Perch, Streete, Bigirimana, Anita, Marveaux, Sammy Ameobi, Obertan, Abeid, Cisse, Shola Ameobi, Ranger.