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Stay with us for a comprehensive match report and all the key reaction from Roberto Mancini and Roberto Martinez.
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Di Santo does well to wriggle free on the byline and cross, with Gomez and Zabaleta tangling in the area and in some pain.
90+3
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Lazy backpass from Balotelli briefly interests Kone, but Hart is alive to the danger and clears.
90+2
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Three additional minutes will be played, and we're already well into the first of those.
90+1
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Now Balotelli feeds the on-rushing Toure, who earns a corner.
90
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Zabaleta makes an excellent run but is ignored by Silva, who instead finds Kolarov out on the left, but his cross is too hard for the City attackers.
89
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Full-time is rapidly approaching now and there looks to be no way back for Wigan.
88
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Lopez is penalised for a challenge on Yaya Toure near the halfway line.
85
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Nastasic has to be alert to deny Kone at the near post.
82
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Toure rampages forward and exchanges passes with Silva before driving a shot well over the bar.
79
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Maicon probably should have made it 3-0 there, but he fires wide after racing onto Boyce's attempted clearance.
78
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This scoreline is a touch harsh on Wigan, who have more than matched Man City for long periods. But this is why one of these sides will be battling for the title, while the other is more likely to be scrapping against relegation.
76
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Absolute peach of a finish from James Milner, unleashing an unstoppable effort from the edge of the box into the top corner after being found by Gareth Barry.
72
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Wigan look for an instant response and Hart has to be alert to push away Jones' free-kick.
71