Leeds caretaker-boss Neil Redfearn could hand Denmark international Casper Sloth his debut as the club start life without sacked head-coach Dave Hockaday.
Former Aarhus midfielder Sloth, who signed a three-year deal this week, may be one of numerous changes following the midweek Capital One Cup defeat to Bradford.
Midfielder Luke Murphy and defender Sam Byram are both suspended and another midfielder, Rodolph Austin, remains sidelined due to the hamstring injury that ruled him out at Valley Parade.
Defender Gaetano Berardi is recovering from concussion sustained in training and Souleymane Doukara, Aidy White (both ankle) and Steve Morison are still out.
Dougie Freedman will likely ring the changes again for Bolton, but former Leeds striker Jermaine Beckford will hope for a starting berth.
A Wanderers team featuring nine changes beat Crewe in extra-time in the Capital One Cup on Tuesday night and Beckford's brace means he will be at the forefront of Freedman's mind.
Midfielder Mark Davies is still waiting to get the all-clear to return from a toe injury having hoped to return in time for the Crewe fixture.
Left-back Dean Moxey (foot) could also come back into the fray but Marc Tierney (broken leg) remains some way off a return yet.