Peterborough will hand a debut to goalkeeper Ben Amos when Barnsley visit London Road.
Amos, 19, has been drafted in on loan from Manchester United and will start as first-choice Joe Lewis serves a one-match suspension following his red card at Blackburn in midweek.
Defender Gabriel Zakuani missed that 5-2 defeat at Ewood Park with a hamstring injury but is expected to be fit while striker Craig Mackail-Smith will be handed a late fitness test.
Mackail-Smith scored his sixth goal of the season against Scunthorpe last weekend but was left out at Blackburn with a knock and manager Darren Ferguson will make a late decision.
New signings Ryan Bennett and Scott Griffiths will hope to make their debuts after being cup-tied in midweek, while on-loan Tottenham midfielder Danny Rose also returns.
Charlie Lee went off with a bruised foot and is a doubt, left-back Tom Williams is out with an ankle injury but Paul Coutts is fit after his foot problem.
Barnsley pair Adam Hammill and Emil Hallfredsson are both doubtful for the trip.
But on-loan Stoke defenders Ryan Shotton and Carl Dickinson and midfielder Nathan Doyle, on loan from Hull, plus striker Andy Gray are all expected to return to the squad after being ineligible for the midweek Carling Cup clash.
Winger Hammill and Iceland international midfielder Hallfredsson both sustained knocks in the defeat to Manchester United and could undergo late fitness tests.
Martin Devaney would have been in contention should Hammill miss out, but he has joined MK Dons on loan this week, so Jamal Campbell-Ryce comes into contention.
Manager Mark Robins has no other new injury or suspension worries as his side look to bounce back from two successive league defeats, which have left them four points above the relegation zone.