Sheffield United welcome back experienced defender David Unsworth to the squad but could be missing a handful of other players against QPR.
Craig Short, Leigh Bromby and Alan Quinn all missed the Sheffield derby with knocks and are likely to be absent once again.
That means on-loan Neill Collins, who made his Blades bow in that match, and Chris Armstrong could continue in defence with Unsworth slotting in at left-back.
Phil Jagielka has suffered from illness recently but is expected to be fit, while Danny Webber could make his return to the side after hamstring problems.
Alan Wright has left the club to join Derby on a one month loan deal.
Marc Bircham should return to the QPR squad after missing the .
2-1 defeat at Crystal Palace with a calf injury.
His return is welcome news for caretaker-manager Gary Waddock, who learned earlier this week that winger Martin Rowlands would miss the remainder of the season with a knee injury.
Waddock will also be without winger Gareth Ainsworth and defender Mauro Milanese at Bramall Lane. Both picked up their fifth bookings of the season in the 1-0 win over Millwall on February 11, and serve one-match bans.
Waddock had also hoped that skipper Kevin Gallen might recover from a back injury to feature in this match, but the 30-year-old forward missed the reserve clash with Reading.
Goalkeeper Simon Royce (hip) and defender Dominic Shimmin (groin) miss out, while striker Paul Furlong hopes for a recall after stepping off the bench to score at Palace.