Ipswich will be without midfielders Alan Quinn and David Norris when Blackpool visit Portman Road.
The duo both picked up their fifth bookings of the season during the 3-0 defeat at Swansea last weekend and will serve one-match suspensions.
That should see Veliche Shumulikoski come back into the side after he came through a midweek international with Macedonia unscathed while Danny Haynes could be handed the other vacant place.
Argentinian winger Luciano Civelli played for an hour in midweek as the reserves thrashed Colchester 9-2 but he is still short of match fitness and will not feature.
Dean Bowditch scored four goals in the second string clash and will hope to be handed a place on the bench.
Full-back Moritz Volz remains sidelined with his groin problem despite returning to light training while Ivan Campo is also out with a torn calf muscle, meaning Pim Balkestein is set to keep his place.
Blackpool will be without on-loan midfielder Charlie Adam through suspension for the trip.
The Rangers man was shown a straight red card on his debut in last weekend's 3-2 home defeat to Doncaster following a challenge on Richie Wellens.
Adam will serve a three-match ban for violent conduct, ruling him out of the games against Ipswich, Derby and Watford.
However, the Seasiders are boosted by the returns of goalkeeper Paul Rachubka and midfielder Claus Jorgensen after one and three-match suspensions respectively.
Striker Ben Burgess (knee) and midfielder Keith Southern (ankle) are definitely sidelined but skipper Rob Edwards could earn a recall after being left out of the 16 against Doncaster.
Midfielder Francesco Carratta, who arrived on a free transfer from Royal Antwerp, could also come into contention.