Luton are without a number of players for the home match against Plymouth, which could see them drop into League One.
If the Hatters lose to Ian Holloway's men, Barnsley and Hull win and Leicester avoid defeat, they would be relegated from the Championship with three matches remaining.
And a desperate situation for manager Kevin Blackwell has been compounded by several injury problems.
Defenders Leon Barnett (hamstring) and Sol Davis (calf) are on the road to recovery but will not be fit enough to feature, while full-back Kevin Foley continues to struggle with heel and ankle trouble.
Midfielder Ahmet Brkovic and forward Dean Morgan could miss the remainder of the campaign with facial and ankle injuries respectively, while utility-man Paul Underwood will not play again this term, despite returning to action for the reserves in midweek.
Forward Sam Parkin remains a long-term casualty with an ankle injury.
On-loan Chelsea winger Scott Sinclair completes his three-month spell with Plymouth following the clash at relegation-haunted Luton.
The 18-year-old was used as a second-half substitute in Monday's 3-0 home win over Leicester, which hoisted Argyle back up to 13th after three successive away defeats.
The Pilgrims were boosted by the immediate recall of French centre-back Mat Doumbe following his two-match ban and he started in place of on-loan Ferencvaros defender Krisztian Timar.
Hungary international midfielder Akos Buzsaky was restored to the right wing in place of Bojan Djordjic.
They were Ian Holloway's only two changes to a side that had performed well despite a 2-1 loss at Leeds, and he is likely to make even less at Luton following Plymouth's comfortable win over the Foxes.