Kaspars Gorkss, Ben Burgess and Claus Jorgensen scored to earn Blackpool their third win in four and a first victory over Lancashire rivals Burnley since April 1998.
Latvian defender Gorkss' firm header - his second goal in two home games - earned the Seasiders a half-time lead before Burgess and Jorgensen scored in quick succession.
Burgess converted Jorgensen's cross with a well-placed header after 58 minutes before the midfielder netted a sublime half-volley from outside the box.
The result ended Burnley's formidable record away from Turf Moor since Owen Coyle was installed as boss in late November.
They had won three and drawn one of the previous four games on the road but looked devoid of options in attack and struggled in defence ahead of the FA Cup third round tie with Arsenal.
Ben Burgess and Chris McCann traded early chances before Gary Taylor-Fletcher and Scott Vernon each failed to trouble Gabor Kiraly with tame shots on the turn.
Shaun Barker then rose to meet the game's first corner after 16 minutes but could not find the target with a free header. It was a warning to Burnley of things to come.
The visitors' top scorer Andy Gray, returning from injury, was at the centre of all their good work, making a continual nuisance of himself.
The striker won a free-kick on the right and Robbie Blake floated in a cross which was met by Stephen Caldwell, but the defender, who made six league appearances while on loan at Bloomfield Road from Newcastle in 2001, could only head over.
Gorkss then met Wes Hoolahan's corner from the left after 23 minutes with a firm header which eluded Kiraly and bounced in off the right-hand upright to give the Seasiders the lead.
Coyle suffered a further blow when David Unsworth limped off after 32 minutes.
And it almost got worse for the Clarets when Jorgensen's shot from 25 yards took a wicked deflection to wrong-foot Kiraly, but he recovered to make a smart save to his left.
Paul Rachubka saved well from Blake's 20-yard free-kick as Burnley struggled to test the Seasiders' stopper.
A tepid opening 14 minutes to the second half was brought to a close when Hoolahan found Jorgensen on the overlap on the left and Burgess leapt high at the back post to head back across goal and into the net.
And within five minutes Burnley's deficiencies in defence were once again exposed when the ball was half cleared and fell to Jorgensen, whose sweetly struck half-volley sailed past Kiraly.
Hoolahan later broke forward and saw his left-foot shot across goal go a yard wide before three Blackpool substitutes had opportunities.
David Fox's swerving left-foot volley was saved, Andy Morrell had a strike ruled out for offside and Bartosz Slusarski headed over as Blackpool searched for a fourth.
Teams
Blackpool Rachubka, Crainey, Barker, Jackson, Gorkss,Taylor-Fletcher (Fox 79), Jorgensen, Flynn, Hoolahan,Vernon (Morrell 75), Burgess (Slusarski 86).
Subs Not Used: Evatt, Welsh.
Booked: Gorkss.
Goals: Gorkss 23, Burgess 59, Jorgensen 63.
Burnley Kiraly, Alexander, Caldwell, Unsworth (Jordan 31),Harley, James O'Connor, McCann, Lafferty (Jones 71), Elliott,Gray, Blake (Akinbiyi 56).
Subs Not Used: Jensen, Garreth O'Connor.
Booked: Lafferty, McCann.
Att: 9,599
Ref: Andre Marriner (W Midlands).