Manchester United manager Sir Alex Ferguson will again ring the changes for the Carling Cup match against Barnsley at Oakwell on Tuesday.
Promising striker Danny Welbeck could be given a run-out after getting the goal that brought down Wolves in the last round. Midfielder Darren Fletcher might also feature if he recovers from a groin injury that ruled him out of the defeat at Liverpool on Sunday.
Senior professionals like Michael Owen, Gary Neville, Paul Scholes and Wes Brown are all set to be involved against the Coca-Cola Championship side, managed by former Old Trafford striker Mark Robins.
Barnsley will be without on-loan trio Ryan Shotton, Carl Dickinson and Nathan Doyle plus striker Andy Gray.
Stoke defenders Shotton and Dickinson and Hull midfielder Doyle have all played for their parent clubs earlier in the competition while Gray played for Charlton in the first round before his move to Barnsley in late August.
Otherwise, manager Mark Robins has a full-strength squad to choose from, with no new injury problems following Saturday's 3-2 home defeat to Bristol City.
Robins must decide whether to recall Brazilian midfielder Anderson De Silva and the rested Jon Macken to his starting line-up while fellow striker Daniel Bogdanovic was on the scoresheet on Saturday.
Barnsley won at Lincoln and Reading in rounds one and two respectively and beat Burnley 3-2 at Oakwell in the third round to book a fourth-round clash with Robins' former club.
Man Utd (from): Kuszczak, Foster, De Laet, Neville, Brown, J Evans, Dudgeon, Fabio, Rafael, Tosic, Gibson, C Evans, Eikrem, Carrick, Fletcher, Scholes, Valencia, Nani, Owen, Welbeck, Macheda, King.