Worcestershire's promotion drive ran into a road block in the LV= County Championship at Derby when an inspired career-best spell of spin bowling from Wes Durston sent them crashing to a 138-run defeat.
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The Division Two leaders collapsed dramatically after tea in pursuit of a target of 268 and were bowled out for 129 runs to give Derbyshire a third consecutive championship victory for the first time since 2002.
Durston took five for 19 to condemn Worcestershire to a second consecutive defeat after Derbyshire skipper Wayne Madsen had set his side up with 98 out of 296 with New Zealand seamer Mitchell McClenaghan taking five for 78.
Madsen, who was dropped by Richard Oliver at square leg of Charlie Morris on 13, moved through the gears in the morning, scoring 76 of Derbyshire's 123 that gave them a 239-run lead at lunch.
Five wickets tumbled for 28 in the afternoon as Derbyshire chased quick runs with Madsen falling two short of what would have been his second championship hundred of the season when he played on to give McClenaghan his first five wicket haul in England.
It left Worcestershire to score at just under five an over on a pitch that had offered something for the bowlers throughout the game and the chase started badly with Oliver recording his first duck in championship cricket.
Mark Footitt's opening burst was always likely to have a big bearing on the outcome of the match and he removed Oliver for the second time in the game when the opener lobbed back a return catch off a ball that appeared to stop on him.
Tom Fell had resisted for close on five hours in the first innings but this time he lasted only 11 balls before Footitt beat him for pace and knocked back his off stump in the fifth over.
Alexei Kervezee took three fours from Footitt's next over but when he whipped Wayne White, who had replaced Tony Palladino after six consecutive maidens, he was brilliantly caught one-handed above his head by Ben Slater at square leg.
At tea, Worcestershire required another 209 from 37 overs but their chances of victory vanished in the space of 10 balls from Durston.
Mitchell top-edged a sweep and was well caught at deep backward square leg by Footitt for 15 from 71 balls and Tom Kohler-Cadmore edged behind when he lunged forward.
Derbyshire scented victory when Durston had Joe Leach caught at slip pushing forward in his next over to leave Worcestershire on the ropes at 89 for six with 29 overs remaining.
Shaaiq Choudhry became Durston's fourth victim when he was caught at silly point and Durston held a sharp slip catch in the next over when Ben Cox edged David Wainwright.
Jack Shantry and McClenaghan held out for 13.2 overs but Durston switched ends and had Shantry pouched at short leg before Chesney Hughes bowled McClenaghan with 10.2 overs remaining.
Worcestershire's director of cricket Steve Rhodes said: "Derbyshire got the toss right and selection right with two spinners coming into their own as the wicket really turned and bounced and they outplayed us and certainly deserved to win.
"If we had held a few catches they wouldn't have got the score they would have done and we lost our top order within 25 overs and you are really struggling then to survive."