England claimed a 2-1 lead in the Investec Test Series as India collapsed to an innings-and-54-run defeat inside three days at Emirates Old Trafford.
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England did almost all the damage after tea, claiming nine wickets for 128 during an exhilarating session.
The hosts' success was all the more remarkable coming without one of the main pace spearheads, Stuart Broad, who was struck by a bouncer while batting in the afternoon and did not bowl.
The improving off-spin of Moeen Ali again proved problematic for the Indians as the Worcestershire all-rounder claimed four for 39 in the tourists' paltry 161.
Chris Woakes began the rot before tea after England had claimed a first-innings lead of 215 while Chris Jordan finished it off with two wickets in two balls. James Anderson also weighed in with two for 18 in another high-quality effort.
With a poor forecast for the Manchester area on Sunday, England will be glad to have wrapped up such an impressive victory and be heading to the The Oval for next week's fifth Test with an unassailable lead.
The major concern for England in the evening was the fitness of Broad, who was struck on the nose when an 88.1mph bouncer from Varun Aaron passed through the grille of his helmet.
Broad, who has already revealed he will undergo knee surgery at the end of the series, was taken to hospital for an X-ray, with England captain Alastair Cook later confirming the bowler had broken his nose.
The injury overshadowed a superb conclusion England's only innings, in which Joe Root and Jos Buttler continued their excellent work of Friday.
The seventh-wicket pair took their stand to 134 before in-form Root - having passed 50 for the fourth time in four matches, in a summer in which he has also scored a double century - fell for 77.
Root had been watchful, after reaching his half-century in the second over of the morning, while Buttler played more expansively.
The Yorkshire batsman had just started to open up, hitting Aaron for successive boundaries, before gloving a legside catch to MS Dhoni off Pankaj Singh.
That gave the hitherto luckless Pankaj his first Test wicket, having conceded 274 runs in his two matches, and another quickly followed.
Pankaj disguised a slow ball and Buttler tamely chipped to Cheteshwar Pujara at mid-off.
But the wickets were minor victories for India. Buttler had already ridden his luck in being dropped by Virat Kohli on 34 and then being caught well short of his ground on 44, only for Dhoni to miss a run out chance.
England went for lunch with a lead of 173 and looked to up the tempo immediately after the resumption.
Broad hooked Aaron for successive sixes but was then hit in the face attempting a third.
He signalled for treatment immediately but, with a bloodied nose and looking groggy, had to retire hurt. He was seen later in the day leaving the ground for hospital.
The incident did raise concerns about how England's batsmen deal with the short ball after Root and Ali were troubled by the same bowler earlier in the match, but that issue will be addressed in due course.
Woakes added a quick 26 but England's innings ended on 367 when Anderson fell to his arch-rival Ravrindra Jadeja.
India, without having to face Broad, made a more solid start to their second innings than their first - but it soon unravelled.
Murali Vijay, who had earlier flashed wide of the slips, was trapped lbw to become Woakes' first victim of the series.
India tried to consolidate but the match began to hurtle towards a conclusion after Gautam Gambhir gloved a legside catch to Buttler off Anderson with the score 53.
Pujara fell lbw to Ali off the next ball of the innings and Ajinkya Rahane chipped a simple catch back to the same bowler soon after.
Kohli then edged Anderson to Ian Bell at second slip and when Jadeja picked out Chris Jordan in the slips of Ali, India had lost five wickets for 13 runs.
Dhoni tried to be positive to delay the inevitable but his cameo of 27 was ended when Gary Ballance took a fine diving catch at midwicket, giving Ali a fourth wicket.
Jordan should have had the eighth wicket Bhuvneshwar Kumar edged him to Bell on a no ball but the same batsman was run out soon after when he failed to beat an Ali throw while looking for two.
Ravichandran Ashwin clubbed a quick 46 but it mattered little and Jordan completed the match in style.
Aaron first gloved him to Buttler and then he bowled Pankaj first ball with an excellent yorker.