Mohammed Hafeez registered a career-high 86, while Umar Gul picked up five for six as Pakistan beat South Africa by 95 runs at Centurion to win the Twenty20 series 1-0.
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Pakistan made 195 in the second T20 international, the first having been rained off in Durban on Friday, before dismissing the hosts for 100 - the Proteas' lowest-ever T20 total.
Ahmed Shehzad (46) proved a useful partner for Hafeez as the pair put on 83 for the second wicket, while three of Gul's five wickets fell in the South Africans' fifth over to decimate their hopes of reaching the target.
After winning the toss, Pakistan made an impressive start as Nasir Jamshed and Ahmed Shehzad found the boundary regularly, with Kyle Abbott's second over in particular taking punishment as the openers plundered 17.
South Africa got their first breakthrough the next over when Jamshed mistimed a pull to Justin Ontong off the bowling of Lonwabo Tsotsobe for 13.
That brought in Hafeez, whose innings could have ended after one ball following a mix-up between the batsmen which saw them both at the striker's end.
However, Faf Du Plessis missed the stumps at the other end, with the man at mid-on then also having a shy and lacking accuracy.
The hosts were made to pay as the duo helped Pakistan reach 52 after six overs.
The pair's lack of communication did lead to the end of the partnership in the 12th over, though, as they both again ended up at the batsman's end and this time it resulted in an easy run-out.
By then, Shehzad had made 46 from 25 balls in a knock which included six fours and two sixes.
His departure did little to slow down the run-rate as Hafeez hit consecutive maximums off Ontong at the start of the 14th over, the second taking him past his previous best score of 71 as Pakistan moved to 154 for two after 14.
Akmal went four balls later for 11, caught by Du Plessis off Chris Morris, before Hafeez departed in the 17th.
It looked like Hafeez had smashed his 10th boundary, but replays showed he had backed onto his wicket and with the bails dislodged he had to go for a 51-ball 86.
At 170 for three, Pakistan were in a strong position but three balls later Shoaib Malik departed for seven while Kamran Akmal could make just one as they finished 195 for seven.
South Africa seemed set to make a decent fist of a reply when captain AB De Villiers hit Junaid Khan for six in the second over, but Henry Davids departed at the end of the over - caught by Saeed Ajmal for seven.
The next over went for 14, Mohammad Irfan taking some punishment from De Villiers. But it proved a false dawn for the hosts as wickets began to tumble.
Du Plessis, Morris and Ontong all fell to Gul in a fifth over which left South Africa struggling badly at 51 for four.
They were soon five down after De Villiers was bowled by Irfan for 36, before Farhaan Behardien registered a duck, becoming Gul's fourth victim.
David Miller was the next South African back in the pavilion, caught by Shehzad off Hafeez for nine.
Rory Kleinveldt's entertaining 22 from seven deliveries gave the home supporters something to shout about but he was swiftly snared by Hafeez, snapped up by Umar Akmal in the deep.
Robin Peterson (13) was next to perish at the hands of Hafeez, leaving South Africa 98 for nine, and when Abbott became Gul's fifth victim for two it was all over.