| Northampton 27 London Irish 22 |
april 28 Guinness Premiership at Franklin's Gardens. (More) | |
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| London Irish 26 Worcester 16 |
april 15 Guinness Premiership at the Madejski Stadium. (More) | |
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| Harlequins 34 London Irish 17 |
april 7 Guinness Premiership at the Twickenham Stoop. (More) | |
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| London Irish 7 Saracens 22 |
march 23 Guinness Premiership at the Madejski Stadium. (More) | |
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| Bristol 7 London Irish 12 |
march 10 Guinness Premiership at the Memorial Ground. (More) | |
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| London Irish 38 Newcastle 12 |
march 3 Guinness Premiership at the Madejski Stadium. (More) | |
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| Sale 9 London Irish 14 |
february 23 Guinness Premiership at Edgeley Park. (More) | |
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| London Irish 15 Bath 7 |
february 17 Guinness Premiership at the Madejski Stadium. (More) | |
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| Saracens 19 London Irish 8 |
january 28 Guinness Premiership at Vicarage Road. (More) | |
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| Llanelli 20 London Irish 16 |
january 21 Heineken Cup Pool Five at Stradey Park. (More) | |
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| London Irish 23 Toulouse 26 |
january 13 Heineken Cup Pool Five at the Madejski Stadium. (More) | |
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| Gloucester 15 London Irish 3 |
january 1 Guinness Premiership at Kingsholm. (More) | |
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| London Irish 26 Leicester 25 |
december 26 Guinness Premiership at the Madejski Stadium. (More) | |
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| Worcester 14 London Irish 16 |
december 22 Guinness Premiership at Sixways. (More) | |
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| Ulster 29 London Irish 13 |
december 15 Heineken Cup Pool Five at Ravenhill. (More) | |
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| London Irish 29 Ulster 13 |
december 9 Heineken Cup Pool Five at the Madejski Stadium. (More) | |
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| Cardiff Blues 31 London Irish 7 |
december 1 EDF Energy Cup Group B at Cardiff Arms Park. (More) | |
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| London Irish 40 Northampton 5 |
november 26 Guinness Premiership at at the Madejski Stadium. (More) | |
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| Leicester 26 London Irish 18 |
november 18 Guinness Premiership at Welford Road. (More) | |
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| London Irish 11 Gloucester 22 |
november 10 Guinness Premiership at the Madejski Stadium. (More) | |
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| Bath 17 London Irish 21 |
november 4 Guinness Premiership at the Recreation Ground. (More) | |
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| Toulouse 37 London Irish 17 |
october 29 Heineken Cup Pool Five at Stade Ernest Wallon. (More) | |
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| London Irish 25 Llanelli 32 |
october 20 Heineken Cup Pool Five at the Madejski Stadium. (More) | |
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| London Irish 14 Sale 31 |
october 15 Guinness Premiership at the Madejski Stadium. (More) | |
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| Wasps 23 London Irish 13 |
october 8 EDF Energy Cup at Adams Park. (More) | |
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| London Irish 36 Saracens 24 |
september 30 EDF Energy Cup at the Madejski Stadium. (More) | |
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| Newcastle Falcons 21 London Irish 26 |
september 22 Guinness Premiership at Kingston Park. (More) | |
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| London Irish 11 Bristol 23 |
september 16 Guinness Premiership at the Madejski Stadium. (More) | |
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| Wasps 23 London Irish 17 |
september 8 Guinness Premiership at Adams Park. (More) | |
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| London Irish 20 Harlequins 19 |
september 2 Guinness Premiership at the Twickenham. (More) | |
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