Bookies hail 'best-ever Sunday'
Bookmakers William Hill were celebrating their "best-ever Sunday of football" as the four best-backed sides of the day all failed to win.
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Liverpool, Chelsea and Celtic were all 2/7 to win with Spurs 4/5.
Liverpool lost 3-2 at Oldham in the FA Cup, Chelsea were held 2-2 by Brentford, while Celtic lost 3-2 to St Mirren in the Scottish League Cup. Finally, Tottenham went down 2-1 at Leeds.
If you had been farsighted enough to back the three winners and the draw, you would have been given odds of 2,500/1.
William Hill spokesman Joe Crilly said: "We have searched through the bets that have been placed on today's football and as far as we can see, Nostradamus, or his modern day equivalent, has not placed a bet on the outcome of all four of today's big matches.
"It's just incredible and certainly our best-ever Sunday."
Other layers were clearly celebrating the results too as the FA Cup shocks continued following Saturday's upsets, which included non-league Luton winning at Norwich and MK Dons seeing off QPR.
In the outright betting for the competition, the bookies now find it hard to split the two Manchester clubs.
Huddersfield/Leicester v Wigan
MK Dons v Barnsley
Oldham v Everton
Luton v Millwall
Arsenal v Blackburn
Manchester City v Leeds
Manchester United v Reading
Middlesbrough v Brentford/Chelsea
City and United are both 5/2 shots with most firms having been handed home draws against Leeds and Reading respectively.
Stan James side with City, making them 5/2 shots with United at 11/4. However, Hill's go 9/4 United, 5/2 City.
Chelsea are 5/1 chances (BetVictor). They will travel to Middlesbrough if they win the replay against League One Brentford.
Then come Arsenal at 6/1 and Everton at 7s. The Gunners will host Blackburn, while the Toffees will hope to avoid going the same way as Liverpool at Oldham.
Despite the weekend of surprise results, the layers do not fancy a shock winner of the trophy. Leeds can be backed at 100/1, Oldham at 500s and Luton at 1000/1.
Sky Bet football trader Joe Petyt said: "All the teams at the top of the betting will be happy with the draw and will be big favourites to progress.
"This means there is a big gap between the front five and the rest but, as we have already seen with Bradford City this week, it's not impossible for an outsider to reach the final."
Coral have a similar view but are prepared to offer 20/1 about a team from outside the Premier League winning the cup. The last side to do that was West Ham in 1980.
It's 5/1 that a team not in the top flight reaches the final - as Millwall did in 2004.